Trial Related Websites

Health Research Board Trials Methodology Research Network (TMRN)

HRB Clinical Research Co-ordination Ireland (HRB CRCI)

Health Research Board Clinical Research Facility, Galway (HRB CRFG)

Welcome Trust-Health Research Board Clinical Research Facility, St James’s Hospital (WT-HRB CRF SJH)

Clinical Research Facility, University College Dublin

Clinical Research Centre, Royal College of Surgeons in Ireland

Clinical Research Support Centre (Northern Ireland)

Centre for Advanced Medical Imaging, St James’ Hospital Dublin

All Ireland Hub for Trials Methodology Research

HRB Critical Care Clinical Trials Network Ireland (HRB Critical Care CTNI)

HRB Mother & Baby Clinical Trials Network Ireland (HRB Mother & Baby CTNI)

HRB Primary Care Clinical Trial Network Ireland (HRB Primary Care CTNI)

HRB Stroke Clinical Trial Network Ireland (HRB Stroke CTNI)

International Clinical Trials Registration Platform

European Clinical Trials Database (EudraCT)

All Trials Initiative

COMET (Core Outcome Measures in Effectiveness Trials) Initiative Development and application of agreed standardised sets of outcomes, known as ‘core outcome sets’.

EQUATOR Network Library for health research reporting An international initiative that seeks to improve reliability and value of health research literature by promoting transparent and accurate reporting of research studies.

IPPOSI – The Irish Platform for Patient Organisations, Science and Industry Is a patient-led organisation that works with patients, government, industry, science and academia to put patients at the heart of health innovation.

Public Involvement Impact Assessment Framework (Provides tools to assess the impacts of involving members of the public in their research in individual projects)

The James Lind Alliance Priority Setting Partnerships

INVOLVE UK website for resources on Public and Patient Involvement in rese

PPI cost calculator

Clinical Research PPI Working Group repository of resources

Investigators seeking the support of the HRB CRF-C must register with the HRB CRF-UCC if they have not previously done so using HRB CRF-UCC Investigator Application Form

To request HRB CRF-UCC assistance with a funding application an investigator should complete and forward a HRB CRF-UCC Grant Application Support Request Form (GASRF)

HRB-CRCI checklist for guidance on trial costs

“Defining Feasibility and Pilot Studies in Preparation for Randomised Controlled Trials: Development of a Conceptual Framework” by Eldridge S. et al.

“The PRECIS-2 tool: designing trials that are fit for purpose” by Louden et al.

“A process for Decision-making after Pilot and feasibility Trials (ADePT): development following a feasibility study of a complex intervention for pelvic organ prolapse” by Bugge C et al.

“Developing and Evaluating Complex Interventions” by MRC, UK

“Process evaluation of complex interventions: Medical Research Council guidance” by Moore GF. et al.

“Using natural experiments to evaluate population health interventions: Guidance for producers and users of research evidence” by MRC, UK

Consort 2010 Statement: updated guidelines for reporting parallel group randomised trials

SQUIRE Guidelines: provides a framework that authors can use when developing proposals or writing research articles about quality improvement

HIQA Guidelines for the Economic Evaluation of Health Technologies in Ireland (2018)

HIQA Guidelines for the budget Impact Analysis of Health Technologies in Ireland (2018)

HIQA Guidelines for Evaluating the Clinical Effectiveness of Health technologies in Ireland (2011)

IPPOSI has launched an information campaign about clinical trials – www.clinicaltrials.ie and supporting leaflets – that aimed to inform patients and the general public about taking part in clinical trials. This website provides information on clinical trials for:

Adults

Children under 8 years

Children aged 8 to 12 years

Children aged 13 to 18 years

OECD Guidelines on Human Biobanks and Genetic Research Databases

ISBER Best Practices for Repositories

Molecular Medicine Ireland Biobanking Guidelines

NCI Best Practices for Biospecimen Resources

Digital Curation Centre: How to develop a data management and sharing plan and examples

UK Concordat on Open Research Data (July 2016)

Guidelines on FAIR data management plans in Horizon 2020

FAIR data principles FORCE 11

FAIR at the Dutch centre for Life sciences

Registry of Research Data Repositories

Zenodo Data Repository (OpenAIR)

International Clinical Trials Registration Platform

European Clinical Trials Database (EudraCT)

All Trials Initiative

COMET (Core Outcome Measures in Effectiveness Trials) Initiative: development and application of agreed standardised sets of outcomes, known as ‘core outcome sets’

EQUATOR Network Library for health research reporting: an international initiative that seeks to improve reliability and value of health research literature by promoting transparent and accurate reporting of research studies